Testimonials - Receptiva DX

“After my failed transfer with our first donated embryo I felt lost and broken. My doctors believed that I would have no issues carrying a baby, my only infertility diagnosis was premature ovarian reserve, but I refused to give up or move on to my next transfer without more testing. The PA at my office suggested that I research ReceptivaDx, she said it was new but could give me some answers, so I did.

I read that many women may have endometriosis or high levels of BCL6 with no symptoms that could effect an embryo implanting. I immediately wanted this test, it was well worth the money to find out if there could be a reason that my embryo did not implant.

Fortunately and unfortunately my test came back indicating that I had both high levels of BCL6 and endometriosis. My doctor decided that a Laparoscopy would be best, let’s get inside and see what my reproductive organs look like. Turns out I had hydrosalpinx (swollen Fallopian tube) which needed to be removed and endometrium spots, which were also removed.

A few months later I had a 2nd transfer with our remaining donated embryo, and it worked! He is now a perfect, healthy 9month old boy! Do yourself a favor, get this test! I had no symptoms, 1.5 years of infertility treatments and who knows if my journey would have been much shorter or a different outcome if I would have a had this test from the beginning!”

-Kerri Morgan

Hi Mr. Jackson,

It’s been a year and a half since I had that fateful conversation with you about the ReceptivaDx test. You also provided me the chance to converse with Dr. Lessey. That conversation changed my life – fate!! In talking with you, taking the ReceptivaDx test, speaking with Dr. Lessey, then attempting a Lupron treatment protocol, I finally became pregnant with my son after years of trying and failed IVF attempts.

My son Griffin was born this January! And thanks to you and Dr. Lessey for taking time to talk and connect with me, I am holding my son in my arms today – so THANK YOU! I attached some pictures to put some faces behind this story and these people (my family) that you’ve helped.

Sincerely, Meredith

“After a few years of marriage, we decided we would try to start our family. After a year into trying to conceive without success we turned to a prestigious fertility clinic for assistance. After initial workup we were diagnosed with ovulation dysfunction. All other tests came back normal. We first started with clomid and injectable medication, many rounds without success. However, it was learned that I produced numerous eggs each cycle so attempting IUI would be too dangerous with the chance of multiples and we moved on to IVF. Our first egg retrieval resulted in twenty (20) high quality embryos. We used these PGS tested embryos over the course of eight (8) consecutive frozen embryos transfers (FETs) to me. Five (5) times we were pregnant only to lose the pregnancy within the fifth (5th) week of pregnancy. We even tried the Endometrial Receptive Assay (ERA) after having 2 losses and the test said we needed to transfer one day later. After using this new transfer window, we still continued to have losses in the 5th week of pregnancy

After eight (8) PGS transfers, sometimes with two (2) embryos per transfer we were out of embryos and starting to realize we needed a new direction. Gestational carrier was mentioned to us and after doing our research, selecting an agency and being matched with a Gestational Carrier we were ready to move forward. Since we were now out of embryos it was time for another egg retrieval. This time around we got one (1) high quality embryo. This was a drastic change from our first egg retrieval in which we had twenty (20) embryos. We did not PGS test this one (1) embryo but took our chances and did a frozen embryo transfer (FET) to our gestational carrier and she became pregnant (our beautiful son was born full term)! We knew we would love to have another child so we did another egg retrieval while she was pregnant and this time got 3 PGS embryos and froze them. However, we still had no answers as to why I would lose the pregnancy within the 5th week despite all normal lab tests, normal BMI, healthy lifestyle and numerous second opinions. We now had confirmation that our embryo could develop into a healthy baby.

While our gestational carrier was pregnant, we continued to pursue second opinions. We did our research and learned about the Receptivadx test. We asked our fertility clinic to please run this test for us, however, we had numerous hysteroscopy’s to rule out any issues (none were ever found) and we were told that I did not have endometriosis and at that time our fertility clinic was not using the Receptivadx test. As you can tell, I am persistent and determined. I traveled out of state to meet with a new clinic and doctor to get another opinion. This doctor believed my issue was a uterine receptive issue and urged me to have the Receptivadx test done. Back in my home state, I met with another clinic and another new doctor. This new doctor thought that my issue could be that I needed to use femera and repeat the ERA test and that femera can help to produce the Beta Integrin 3 required for implantation. He also agreed to run the Receptivadx test so we used femera and repeated the ERA and then also did the Receptivadx test. The results were now that my ERA was completely normal (transfer 5th day- where before it said to transfer 6th day (extra day needed)) and the Receptivadx showed I had the beta integrin 3 but my BCL6 was 3.8. I had another consult (on the phone) with a prestigious doctor in California. She too believed in the Receptivadx and thought that I needed to use depot Lupron. All of this investigation and the Receptivadx test occurred while our gestational carrier was pregnant.

Once our beautiful son was born and we were overjoyed but also longed for a sibling for him. When he was three (3) months old I went back to my original fertility clinic, showed them the results from the Receptivadx and said that I would like to use one (1) of our three (3) PGS embryos on myself but that I wanted to use the Receptivadx protocol – depot Lupron and femera. The new doctor at my original clinic was very open to this and we started immediately by having me take the first depot Lupron shot, 30 days later I took a second and then 30 days after that I prepped for a FET. We used stimulation medications in combination with femera, an HCG trigger shot, and then minimal progesterone supplementation, transferred on the 5th day, one (1) PGS embryo and I become pregnant. After the 5th week of pregnancy I couldn’t believe it, it was the first time I had made it this far. Our daughter was born at 38 weeks 3 days perfectly healthy and wonderful! The first cycle using the recommended course of medications following a high BCL6 and it worked. If it weren’t for this test, we would not have our daughter. During my pregnancy I informed my original nurse at our fertility clinic of my pregnancy and protocol. My original doctor from this clinic called me and told me that because of me the clinic was now going to utilize the Receptivadx test for future patients!”

-Emily

“We were losing all hope until we did the ReceptivaDx test. After we did it, we finally had an answer and a way forward. What I wouldn’t give to have been able to do it sooner.”

-Andrea

“We really believe this was the missing link to finally getting us pregnant after trying for ten years and never being pregnant before. We are 30 weeks pregnant on Friday. We are so happy to finally be here. Thanks for all that you do!

-Salina

“After my 3^rd loss, which was a PGT- A normal embryo, my doctors tested me for everything. Receptiva was the only thing that came back as a possible explanation for my losses. I just completed 2 months of Lupron treatment and am scheduled to repeat Receptiva next week to see if the treatment worked. I had no symptoms other than infertility and recurrent pregnancy loss. So, without this test, we may never have found answers. For anyone who has searched for answers everywhere else to no avail, I strongly recommend this test.”

-Lindsay

“Our journey to our miracle baby has been one filled with heartache, frustration and many tears. However, through perseverance and a lot of hope, faith and the RECEPTIVE DX test, I am so happy to report that we finally had our beautiful blessing on 11-11-20.

Back in May of 2017 my husband and I received the devastating news that our naturally conceived little girl had an unbalanced translocation (one chromosome was duplicated and another was deleted). Soon after losing our baby girl we had genetic testing and discovered I was the one who was carrying the translocation and our chances of having a healthy, “normal” baby was very small. So we immediately turned to IVF with PGD/PGS testing.

We found our RE in Sarasota, FL and over the course of three years I did three egg retrievals and of 23 eggs we got only three normals!!! We thought our luck had changed and we would soon be welcoming our baby into our arms and into our hearts. Our biggest hurdle was taken care of, we got normal embryos, unaffected by my translocation, and I already knew I could get pregnant and carry a pregnancy!!

So it was time for our first transfer. Everything was perfect; my body responded well to the transfer meds, my lining was think and perfect; ready for my genetically tested normal embryo. Five days after my transfer I took a home pregnancy test and low and behold, she had stuck and I was pregnant!! Beautiful rising betas and then at five weeks and one day, I started bleeding, my HCG levels dropped and I lost our first perfect embryo. The second embryo never implanted so my RE recommended the ERA, which came back receptive, a good sign. I prepped for my third and final transfer with my own eggs while we chose an egg donor to help us create some more embryos.

Our third embryo transfer was successful and we thought this was going to be our time to become parents, but at five weeks two days, I started bleeding, my HCG levels dropped and I lost our last perfect embryo. At this point, I didn’t want to do another egg retrieval so we turned to donor eggs. Our beautiful secret donor gave us FIVE perfect, genetically tested, “normal” embryos. This will definitely work now! So we thought. We prepped and my body, like always responded great to the meds and so we transferred our first donor egg created embryo. She implanted! And I got a positive pregnancy test…again! Like the two other times before. Then at five weeks three days I started to bleed, my HCG dropped and I lost yet another sweet precious embryo. At this point my RE recommended that my husband and I go to Memphis to speak with a specialist in recurrent early pregnancy loss. This is where we were introduced to Chris Jackson and the Receptive DX biopsy test. The Memphis doctor worked with my FL doctor to carry out this test and it showed that my BCL6 (biomarker for inflammation and endometriosis) was positive and my Beta Three Integrin (protein in the body that holds embryos to the lining) was absent and out of phase! Could this have been my missing link??? The Memphis doctor recommended two months of Depo Lupron and changed my protocol slightly and FINALLY after many years of struggling, I got pregnant and STAYED pregnant. I did start spotting at the five week mark and thought it was all over again, but this baby girl was strong! At 14 weeks I had a massive bleed because of a SCH, but other than that I went on to have a normal, uneventful pregnancy. What a beautiful blessing.

I wanted to share my story because I have been there, disappointment after disappointment, losing all hope, wondering if I was ever going to be a mommy. By sharing my story I pray that I can give some women the strength, courage and renewed hope they need to keep on fighting to find the perfect protocol. I consider the Receptive DX biopsy to be my miracle test, the test that allowed my baby girl to make it into my arms. Stay strong if you are struggling to have a baby, try this test because I know if you are like me we would do ANYTHING to get IVF to work! Wishing you all the best and many blessings ahead.

Hugs!”

-Melissa

“My challenges started at age 16, when I had to have an ovary removed because of a benign solid cyst that had grown to the size of a grapefruit.

My challenges continued at age 25, when I found a lump in my breast that turned out to be an aggressive cancer, requiring surgery, chemo, radiation and 5 years of hormone suppression.

When my husband and I married we knew we wanted to have children, but had to wait for my hormone suppression to complete. We were cleared to start trying in 2016 and anticipated some challenges based on my medical history. We were pleasantly surprised to find out we were pregnant very quickly, but the difficulties continued, and I miscarried at 6-7 weeks.

We kept trying and worked with my OBGYN on a few infertility treatments, but nothing changed. So, in January 2018, we decided to see a fertility specialist.

He started with an ultrasound, where he saw some scarring, which prompted the ReceptivaDX test, confirming that I was BCL6 positive, indicating endometriosis and the need for hormone suppression therapy before an IVF transfer.

The specialist also ordered genetic testing to evaluate egg quality, since chemotherapy can alter DNA. This was another difficult process, as having only one ovary meant the egg volume was halved. It took multiple rounds of harvesting to get the quantity needed. In addition, they discovered that my husband and I are both carriers for cystic fibrosis. So specialized genetic testing would be required when we were finally able to get a large enough embryo population.

Following the genetic testing, they found that there were healthy embryos with the right chromosome count that were also not carriers for CF. It was amazing to get the news that we would be able to have a child that was biologically ours!

The next phase involved hormone suppression to treat the endometriosis, prior to an IVF transfer, which was done over a three-month process. But the first transfer didn’t take.

We tried again, going through the same process and in September of 2019, I was pregnant. We now have a four-month old baby boy!”

-Tiffany

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After my first transfer failed with one of our genetically normal embryos my RE suggested we transfer our only remaining euploid embryo the following month. As much as I wanted to do another FET my gut told me something was wrong and to do more research before we dove into another transfer. Everything from that transfer looked great on paper. Perfect lining, estrogen and progesterone levels were good, normal day 5 embryo. So why did it fail?

During my initial infertility work up I was diagnosed with infertility of tubal origin due to scarring seen on bilateral tubes. I was told it could be due to endometriosis but because I wasn’t having any symptoms other than infertility my doctor did not recommend laparoscopy. I started researching “silent endometriosis” and infertility online and came across articles published by Dr. Lessey which led me to the ReceptivaDx site. I discussed my findings with my RE and he was more than happy to do the endometrial biopsy for me. My H score from the Receptiva test came back at a 4 which indicated high levels of BCL6. While I was happy to finally have an answer as to why my FET had failed and more than likely why I had miscarried a natural pregnancy a month after I had stopped taking birth control a year prior; I was also sad that I hadn’t discovered ReceptivaDx earlier.

From there I did another egg retrieval to bank more euploid embryos followed by 3 months of Lupron depot and letrozole. After I completed the 3 months of Lupron/letrozole we went straight into an FET and I am happy to say that I am 8 months pregnant with a healthy baby boy. My husband and I will be forever grateful for Dr. Lessey and the research he has done. The ReceptivaDx test is easy and relatively inexpensive in comparison to infertility workups/treatments and even more importantly the years of heartache it could save you!

-Andrea L.

At age 36, I was diagnosed with diminished ovarian reserve and was devastated by the news. We chose the option of using donor eggs to conceive. We went through three rounds of IVF with donor eggs resulting in embryo grades AA/AB and received negative pregnancy tests in all three cases. I was told by the doctor that my uterine lining and uterus looked great, and they did not know the reason for failures. I consulted a second physician, Dr. Kutteh in Memphis, TN, who recommended the ReceptivaDx test. From this test, we discovered I had endometriosis and no beta-3 integrin receptors. I discussed my case with Dr. Lessey, and he felt that a regimen of Lupron and Letrozole would be beneficial. For the next transfer cycle, we used the recommended medication regimen, and we implanted two embryos. This resulted in my first positive pregnancy test. Recently, I gave birth to happy, healthy fraternal twin girls. If it wasn’t for Dr. Kutteh’s consultation and Dr. Lessey’s research with Receptiva testing, I wouldn’t be a mom today.

-KB & JB

After nearly four years of trying, two rounds of IUI, two rounds of IVF, countless tests, procedures, and supplements, and a loss, I was losing hope. Neither my doctor or I could figure out why I wasn’t getting and staying pregnant with normal embryos. After my second transfer failed, my doctor suggested the ReceptivaDx test and an ERA. At that point, I was desperate for any answers, but wasn’t sure what we’d find. My ERA came back inconclusive, but I was shocked when my ReceptivaDx results came back showing a high level of the protein associated with inflammation, indicating I most likely have endometriosis. What was so surprising was that I didn’t have the traditional symptoms associated with endo and without this test, we never would have known I have “silent endometriosis.” My doctor put me on a two-month regimen of Lupron Depot ahead of our 3rd transfer and it worked! I’m currently 32 weeks pregnant and really believe this was the missing piece in my fertility journey.

-AL

Instagram influencer Bailey Hawkins shares her fertility journey and how the ReceptivaDx test was the missing puzzle piece that helped her conceive.

Watch Bailey's Testimonial

I was diagnosed with the infamous “unexplained infertility” after all of my initial testing and being unable to conceive on our own. We went directly to IVF as I was advanced maternal age (36) and we had coverage so it made sense. We had 2 egg retrievals were lucky enough to get 6 quality blastocysts that were untested. After my first 2 failed embryo transfers we did an ERA test which was normal. We then had 4 more failed transfers. I knew something was wrong and I didn’t feel like my RE had any intention of trying to find out. After every failed transfer I kept hearing from her “It’s either and embryo issue or a uterine issue”. She had mentioned the ReceptivaDx test but stated it was new and she didn’t think I had endometriosis because I had no symptoms and therefore did not recommend the test. I also had one marker that was consistently positive for antiphospholipid antibody syndrome. I had taken aspirin and lovenox (although I found out I am allergic to Lovenox) prior to transfers with no luck. She told me I had already had all the testing for my uterus and she didn’t think it was a uterine issue. I knew something was wrong! We were out of embryos and it was time for me to move onto another RE who could help me. I started treatment at a new fertility clinic and the first cycle I asked for the ReceptivaDx test and she agreed that I should have this done. My test revealed an elevated BCL6 marker indicating I was positive for endometriosis! It was a relief that I finally had a diagnosis. We decided to leave no stone unturned and were going to test embryos this time. We had an egg retrieval that yielded 2 blastocysts that were both abnormal. The disappointment and feeling of defeat weighed heavy upon us, and here we were back to square one yet again.

It was the end of the year and we decided to change insurances with my job and was lucky enough to change to a university hospital system who had an endometriosis specialist who was also a RE. I decided this was the best course for me and moved clinics in order to see this doctor. He recommended a pelvic MRI, which was normal. We then had our 4^th egg retrieval. This time we got 2 blastocysts and had 1 normal embryo! My doctor recommended 3 months of Lupron depot injections and then a hysteroscopy to make sure my uterus looked good. I had a small amount of scar tissue which was removed, otherwise was told everything was normal. I also met with a perinatologist who started me on an anticoagulant called Fondiparinux prior to the transfer to treat the antiphospholipid antibody syndrome. We had our embryo transfer in January and I finally became pregnant with our baby girl who is due in October! I know that the ReceptivaDx test was absolutely vital in diagnosing my endometriosis as my only symptom was infertility! Had I not had the ReceptivaDx test to diagnose endometriosis, I honestly think the endometriosis would have continued to go untreated and I would not be pregnant today. I am eternally grateful that this test exists, my only regret is not advocating for myself to get the test performed sooner!

-Stephanie K.

It was late 2015 when I started thinking seriously about single parenthood by choice and artificial insemination. When I started working with a reproductive endocrinologist in early 2019, everything looked good and we thought this would be easy. Then I started with IUIs, and it was not easy. After many months of IUIs, my doctor said she thought I had a diminished ovarian reserve (DOR) and would need IVF. I was stunned. I didn’t know much about IVF at that point, but I knew it was a lot more intensive and a lot more expensive. I took some time off to regroup, and then started back, determined to try everything possible. If I didn’t, I knew I would always ask myself, what if?

In my first retrieval, I got 5 eggs, 2 were mature and fertilized, and 1 made it to blastocyst. Even though I knew about the DOR, I was still very disappointed to get so few eggs. I decided to do a second retrieval, thinking even if I could get just one more, I’d have a good chance of success. In my second retrieval, I got 9 eggs, 8 were mature, 4 fertilized, and none survived. That was the hardest week of my treatments. To anyone else, they were a group of cells, but to me they were my babies. I took off work and went to the beach. It was off-season, so it was calm and quiet. The first morning I got up in the dark and sat on the beach wrapped in a blanket to watch the sun rise over the ocean. I needed to be reminded that there is a God; that He is good; and that somehow this would all be alright, even if I didn’t know what “alright” would be. I spent the next 4 days walking for miles up and down the shoreline. One day I saw monarch butterflies on the beach. I’ve been going to this beach town for decades and don’t ever remember seeing butterflies. It felt like a sign that yes, everything would really be alright.

I got back home more resolved and determined than ever. A good friend—my IVF guardian angel—who was also going through fertility treatments and had gotten pregnant told me about the ReceptivaDx test. Her test was negative, but she said she felt like it was a good way to find out before transferring if there could be any problems. I met with one of the practice’s doctors—ironically, my doctor was on maternity leave—and told him I wanted to test everything that could have any impact on my transfer, first of which was the ReceptivaDx test. Initially he said he didn’t want me to fall down a rabbit hole of testing. I didn’t accept that answer. By the end of the conversation, I was getting everything I wanted—full “pregnancy loss” blood work panel, blood test for natural killer cells, and the ReceptivaDx test.

The ReceptivaDx results? Positive. I had mixed emotions; on one hand, it was disappointing. But on the other hand, I felt like I had the answer to the question. Between the DOR and the issues with my endometrium that the ReceptivaDx test brought to light, there was barely a fighting chance for those IUIs to work. I started a two-month treatment of depot Lupron plus letrozole. Those two months of essentially being in menopause were not easy—hot flashes are no joke!—but I kept reminding myself what it was for. Then came the transfer day for my one little embryo. And, miracle of miracles, it stuck! As I write this, I am 17 weeks, 5 days pregnant with my son. At every ultrasound he’s wriggling around, waving those arms, kicking those legs—and I love him for it. I love him for being strong, I love him for hanging on, I love him for being as stubborn and determined as I am.

I 100% believe that if it were not for the Receptiva test, I would not have this miracle growing within me. I am so glad that I advocated to have the test done before transferring the one embryo I had, and I really wish this test would just be part of the tests that all fertility patients have before even starting IVF. If there is any piece of advice I would give to other people dealing with infertility, it would be to advocate for yourself. There’s a fine line between trusting the doctors will do what is right and telling them what you want. And before you transfer and take a risk of your embryo not implanting, I highly recommend you tell them you want this test. It might make all the difference—I know it did for me.

– Alyssa C.

“After almost 3 years of unexplained infertility, 4 failed medicated IUI’s, and 3 failed embryo transfers, we felt completely defeated, hopeless, and unsure of our next steps. Was this the end of the road for us? Could we handle any more emotionally, physically, and financially? We completed all of the normal testing and originally my doctor could not find any reason why we weren’t getting pregnant and why each embryo transfer failed to implant. It was devastating and I was determined to try and find more answers to at least provide more closure or give us some hope before entering into one more egg retrieval. After IVF failed, we sought out a second opinion and our new fertility doctor, Dr. Barry Ripps, recommended doing the ReceptivaDx biopsy. My results came back very elevated and this was our first sign of hope that we finally found SOMETHING wrong. Based on that information we decided to do a laparoscopy which found mild, silent endometriosis and I became pregnant naturally 3 weeks after surgery!!! It’s an absolute miracle and I’m endlessly grateful for the ReceptivaDx test and the research that is currently being done to investigate the link between unexplained infertility and silent endometriosis. I only hope the ReceptivaDx test becomes more commonplace for patients with unexplained infertility who want to investigate endometriosis BEFORE trying IVF to increase the chances of success with a laparoscopy or Depot Lupron! I can’t thank you enough for giving us hope and answers when we least expected it. We cannot wait to welcome home our little miracle baby girl in October 2022!”

-Caroline C.