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“After my failed transfer with our first donated embryo I felt lost and broken. My doctors believed that I would have no issues carrying a baby, my only infertility diagnosis was premature ovarian reserve, but I refused to give up or move on to my next transfer without more testing. The PA at my office suggested that I research ReceptivaDx, she said it was new but could give me some answers, so I did.

I read that many women may have endometriosis or high levels of BCL6 with no symptoms that could effect an embryo implanting. I immediately wanted this test, it was well worth the money to find out if there could be a reason that my embryo did not implant.

Fortunately and unfortunately my test came back indicating that I had both high levels of BCL6 and endometriosis. My doctor decided that a Laparoscopy would be best, let’s get inside and see what my reproductive organs look like. Turns out I had hydrosalpinx (swollen Fallopian tube) which needed to be removed and endometrium spots, which were also removed.

A few months later I had a 2nd transfer with our remaining donated embryo, and it worked! He is now a perfect, healthy 9month old boy! Do yourself a favor, get this test! I had no symptoms, 1.5 years of infertility treatments and who knows if my journey would have been much shorter or a different outcome if I would have a had this test from the beginning!”

-Kerri Morgan

Hi Mr. Jackson,

It’s been a year and a half since I had that fateful conversation with you about the ReceptivaDx test. You also provided me the chance to converse with Dr. Lessey. That conversation changed my life – fate!! In talking with you, taking the ReceptivaDx test, speaking with Dr. Lessey, then attempting a Lupron treatment protocol, I finally became pregnant with my son after years of trying and failed IVF attempts.

My son Griffin was born this January! And thanks to you and Dr. Lessey for taking time to talk and connect with me, I am holding my son in my arms today – so THANK YOU! I attached some pictures to put some faces behind this story and these people (my family) that you’ve helped.

Sincerely, Meredith

“After a few years of marriage, we decided we would try to start our family. After a year into trying to conceive without success we turned to a prestigious fertility clinic for assistance. After initial workup we were diagnosed with ovulation dysfunction.  All other tests came back normal. We first started with clomid and injectable medication, many rounds without success. However, it was learned that I produced numerous eggs each cycle so attempting IUI would be too dangerous with the chance of multiples and we moved on to IVF.  Our first egg retrieval resulted in twenty (20) high quality embryos. We used these PGS tested embryos over the course of eight (8) consecutive frozen embryos transfers (FETs) to me. Five (5) times we were pregnant only to lose the pregnancy within the fifth (5th) week of pregnancy. We even tried the Endometrial Receptive Assay (ERA) after having 2 losses and the test said we needed to transfer one day later. After using this new transfer window, we still continued to have losses in the 5th week of pregnancy

After eight (8) PGS transfers, sometimes with two (2) embryos per transfer we were out of embryos and starting to realize we needed a new direction. Gestational carrier was mentioned to us and after doing our research, selecting an agency and being matched with a Gestational Carrier we were ready to move forward.  Since we were now out of embryos it was time for another egg retrieval. This time around we got one (1) high quality embryo. This was a drastic change from our first egg retrieval in which we had twenty (20) embryos. We did not PGS test this one (1) embryo but took our chances and did a frozen embryo transfer (FET) to our gestational carrier and she became pregnant (our beautiful son was born full term)! We knew we would love to have another child so we did another egg retrieval while she was pregnant and this time got 3 PGS embryos and froze them.   However, we still had no answers as to why I would lose the pregnancy within the 5th week despite all normal lab tests, normal BMI, healthy lifestyle and numerous second opinions. We now had confirmation that our embryo could develop into a healthy baby.

While our gestational carrier was pregnant, we continued to pursue second opinions. We did our research and learned about the Receptivadx test. We asked our fertility clinic to please run this test for us, however, we had numerous hysteroscopy’s to rule out any issues (none were ever found) and we were told that I did not have endometriosis and at that time our fertility clinic was not using the Receptivadx test. As you can tell, I am persistent and determined. I traveled out of state to meet with a new clinic and doctor to get another opinion. This doctor believed my issue was a uterine receptive issue and urged me to have the Receptivadx test done. Back in my home state, I met with another clinic and another new doctor. This new doctor thought that my issue could be that I needed to use femera and repeat the ERA test and that femera can help to produce the Beta Integrin 3 required for implantation.  He also agreed to run the Receptivadx test so we used femera and repeated the ERA and then also did the Receptivadx test. The results were now that my ERA was completely normal (transfer 5th day- where before it said to transfer 6th day (extra day needed)) and the Receptivadx showed I had the beta integrin 3 but my BCL6 was 3.8. I had another consult (on the phone) with a prestigious doctor in California. She too believed in the Receptivadx and thought that I needed to use depot Lupron. All of this investigation and the Receptivadx test occurred while our gestational carrier was pregnant.

Once our beautiful son was born and we were overjoyed but also longed for a sibling for him. When he was three (3) months old I went back to my original fertility clinic, showed them the results from the Receptivadx and said that I would like to use one (1) of our three (3) PGS embryos on myself but that I wanted to use the Receptivadx protocol –  depot Lupron and femera. The new doctor at my original clinic was very open to this and we started immediately by having me take the first depot Lupron shot, 30 days later I took a second and then 30 days after that I prepped for a FET. We used stimulation medications in combination with femera, an HCG trigger shot, and then minimal progesterone supplementation, transferred on the 5th day, one (1) PGS embryo and I become pregnant. After the 5th week of pregnancy I couldn’t believe it, it was the first time I had made it this far. Our daughter was born at 38 weeks 3 days perfectly healthy and wonderful! The first cycle using the recommended course of medications following a high BCL6 and it worked. If it weren’t for this test, we would not have our daughter. During my pregnancy I informed my original nurse at our fertility clinic of my pregnancy and protocol. My original doctor from this clinic called me and told me that because of me the clinic was now going to utilize the Receptivadx test for future patients!”

-Emily

“We were losing all hope until we did the ReceptivaDx test. After we did it, we finally had an answer and a way forward. What I wouldn’t give to have been able to do it sooner.”

-Andrea

“We really believe this was the missing link to finally getting us pregnant after trying for ten years and never being pregnant before. We are 30 weeks pregnant on Friday. We are so happy to finally be here. Thanks for all that you do!

-Salina

“After my 3rd loss, which was a PGT- A normal embryo, my doctors tested me for everything. Receptiva was the only thing that came back as a possible explanation for my losses. I just completed 2 months of Lupron treatment and am scheduled to repeat Receptiva next week to see if the treatment worked. I had no symptoms other than infertility and recurrent pregnancy loss. So, without this test, we may never have found answers. For anyone who has searched for answers everywhere else to no avail, I strongly recommend this test.”

-Lindsay

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“Our journey to our miracle baby has been one filled with heartache, frustration and many tears. However, through perseverance and a lot of hope, faith and the RECEPTIVE DX test, I am so happy to report that we finally had our beautiful blessing on 11-11-20.

Back in May of 2017 my husband and I received the devastating news that our naturally conceived little girl had an unbalanced translocation (one chromosome was duplicated and another was deleted). Soon after losing our baby girl we had genetic testing and discovered I was the one who was carrying the translocation and our chances of having a healthy, “normal” baby was very small. So we immediately turned to IVF with PGD/PGS testing.

We found our RE in Sarasota, FL and over the course of three years I did three egg retrievals and of 23 eggs we got only three normals!!!  We thought our luck had changed and we would soon be welcoming our baby into our arms and into our hearts. Our biggest hurdle was taken care of, we got normal embryos, unaffected by my translocation, and I already knew I could get pregnant and carry a pregnancy!!

So it was time for our first transfer.  Everything was perfect; my body responded well to the transfer meds, my lining was think and perfect; ready for my genetically tested normal embryo. Five days after my transfer I took a home pregnancy test and low and behold, she had stuck and I was pregnant!! Beautiful rising betas and then at five weeks and one day, I started bleeding, my HCG levels dropped and I lost our first perfect embryo. The second embryo never implanted so my RE recommended the ERA, which came back receptive, a good sign. I prepped for my third and final transfer with my own eggs while we chose an egg donor to help us create some more embryos.

Our third embryo transfer was successful and we thought this was going to be our time to become parents, but at five weeks two days, I started bleeding, my HCG levels dropped and I lost our last perfect embryo. At this point, I didn’t want to do another egg retrieval so we turned to donor eggs. Our beautiful secret donor gave us FIVE perfect, genetically tested, “normal” embryos.  This will definitely work now! So we thought. We prepped and my body, like always responded great to the meds and so we transferred our first donor egg created embryo. She implanted!  And I got a positive pregnancy test…again! Like the two other times before. Then at five weeks three days I started to bleed, my HCG dropped and I lost yet another sweet precious embryo. At this point my RE recommended that my husband and I go to Memphis to speak with a specialist in recurrent early pregnancy loss.  This is where we were introduced to Chris Jackson and the Receptive DX biopsy test. The Memphis doctor worked with my FL doctor to carry out this test and it showed that my BCL6 (biomarker for inflammation and endometriosis) was positive and my Beta Three Integrin (protein in the body that holds embryos to the lining) was absent and out of phase! Could this have been my missing link???  The Memphis doctor recommended two months of Depo Lupron and changed my protocol slightly and FINALLY after many years of struggling, I got pregnant and STAYED pregnant. I did start spotting at the five week mark and thought it was all over again, but this baby girl was strong! At 14 weeks I had a massive bleed because of a SCH, but other than that I went on to have a normal, uneventful pregnancy. What a beautiful blessing.

I wanted to share my story because I have been there, disappointment after disappointment, losing all hope, wondering if I was ever going to be a mommy. By sharing my story I pray that I can give some women the strength, courage and renewed hope they need to keep on fighting to find the perfect protocol.  I consider the Receptive DX biopsy to be my miracle test, the test that allowed my baby girl to make it into my arms.  Stay strong if you are struggling to have a baby, try this test because I know if you are like me we would do ANYTHING to get IVF to work!  Wishing you all the best and many blessings ahead.

Hugs!”

-Melissa

“My challenges started at age 16, when I had to have an ovary removed because of a benign solid cyst that had grown to the size of a grapefruit.

 My challenges continued at age 25, when I found a lump in my breast that turned out to be an aggressive cancer, requiring surgery, chemo, radiation and 5 years of hormone suppression.

When my husband and I married we knew we wanted to have children, but had to wait for my hormone suppression to complete. We were cleared to start trying in 2016 and anticipated some challenges based on my medical history. We were pleasantly surprised to find out we were pregnant very quickly, but the difficulties continued, and I miscarried at 6-7 weeks.

We kept trying and worked with my OBGYN on a few infertility treatments, but nothing changed. So, in January 2018, we decided to see a fertility specialist.

He started with an ultrasound, where he saw some scarring, which prompted the ReceptivaDX test, confirming that I was BCL6 positive, indicating endometriosis and the need for hormone suppression therapy before an IVF transfer.

The specialist also ordered genetic testing to evaluate egg quality, since chemotherapy can alter DNA. This was another difficult process, as having only one ovary meant the egg volume was halved. It took multiple rounds of harvesting to get the quantity needed. In addition, they discovered that my husband and I are both carriers for cystic fibrosis. So specialized genetic testing would be required when we were finally able to get a large enough embryo population.

Following the genetic testing, they found that there were healthy embryos with the right chromosome count that were also not carriers for CF. It was amazing to get the news that we would be able to have a child that was biologically ours!

The next phase involved hormone suppression to treat the endometriosis, prior to an IVF transfer, which was done over a three-month process.  But the first transfer didn’t take.

We tried again, going through the same process and in September of 2019, I was pregnant. We now have a four-month old baby boy!”

-Tiffany

The ReceptivaDxTM Test was developed by CiceroDx in conjunction with Pathology Consultants, Inc. of Greenville, SC. Pathology Consultants, Inc. is a laboratory certified under the Clinical Laboratory Improvement Amendments (CLIA). As with other laboratory-developed tests, this testing service has not been cleared or approved by the US FDA or any other federal regulatory agencies. Data have not been submitted to or evaluated by Federal regulatory agencies and the test is not for sale as an In Vitro Diagnostic (IVD) in the US or the EU.


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