Unexplained Infertility

Planning for a family and then dealing with infertility can be a heartbreaking journey, full of uncertainty and frustration. Many women experience failed IVF, recurrent pregnancy loss, or both. If you’ve gone through various fertility treatments without success, you might start to feel like you’re running out of options, especially when doctors can’t seem to find the answers. That’s why we developed the ReceptivaDx test. This first-of-its-kind test is designed to help you get to the root of unexplained infertility, restoring your hope in the chances of a successful pregnancy.


75% of women with unexplained infertility will test positive for BCL6

What is ReceptivaDxTM?

ReceptivaDx is a test performed on an endometrial biopsy that determines whether a woman has an inflammatory  condition most often caused by endometriosis. Endometriosis is the presence of inflamed uterine tissue on the outside walls of the uterus. Often, endometriosis has few noticeable symptoms, which is why it can remain undetected for so long and why it is sometimes referred to as “silent” endometriosis.


Extrauterine tissue growth is not uncommon, nor is it particularly dangerous; however, it has been proven to interfere with fertility and egg implantation. Tissue growth on the outside of the uterus is high in a protein called BCL6. The ReceptivaDx test detects the presence of BCL6 in the patient’s uterine lining, helping medical professionals give you a clear diagnosis of the issue causing infertility.

ReceptivaDxTM (BCL6 Test) Predicts Chances for a Successful Transfer and Successful Pregnancy

Female health care worker sitting at a desk in front of a computer

How Do the Test Results Help Me?

A positive ReceptivaDx test indicates that there are high traces of BCL6; this means that the patient likely has endometriosis. If that is the case, medical professionals can then proceed with either laparoscopic surgery or hormone treatment to remove the problematic tissue. In published studies, 75% of women with unexplained infertility will test positive for BCL6. Our ReceptivaDx test has helped countless women and physicians determine a clear course of action and accurately predict the chances of a successful pregnancy.

If the test results are negative, that means that there are no abnormal amounts of BCL6. Patients with negative test results have a low probability of endometriosis as a possible cause of infertility. With this information, a patient and her physician can narrow down other potential causes and consult about further courses of action.

Without further treatment, women testing positive for ReceptivaDx are 5 times less likely to succeed in IVF than women testing negative. Women who test positive have less than an 18% chance of pregnancy in the next transfer attempt and less than an 11% success rate resulting in a live birth. Women who test negative have more than a 70% chance of pregnancy in the next transfer attempt and more than a 59% success rate resulting in a live birth.

Where’s My Nearest Center?

ReceptivaDxTM Center Finder

Considering ReceptivaDx? You’re well on your way to finding the answers you seek. Use our ReceptivaDxTM Center Finder to locate a provider near you!

We are adding new IVF Centers every week to our list of sites where ReceptivaDx testing is offered. If you do not see a center close by, give us a call at (800) 795-5385 as some centers are not currently listed. You can also contact us at any time for a free phone consultation. Our experts will be more than happy to answer any questions you may have about ReceptivaDx. We’re here to offer you support and solutions!

ReceptivaDxTM Testing Can Help Make a Difference

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The ReceptivaDxTM Test was developed by Cicero Diagnostics in conjunction with Pathology Consultants, Inc. of Greenville, SC. Pathology Consultants, Inc. is a laboratory certified under the Clinical Laboratory Improvement Amendments (CLIA). As with other laboratory-developed tests, this testing service has not been cleared or approved by the US FDA or any other federal regulatory agencies. Data have not been submitted to or evaluated by Federal regulatory agencies and the test is not for sale as an In Vitro Diagnostic (IVD) in the US or the EU.

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