Shining a new light in the most challenging times

ReceptivaDx – a path forward for unexplained infertility, failed IVF, and recurrent pregnancy loss

Planning for a family and then dealing with infertility can be a heartbreaking journey, full of uncertainty and frustration. Many women experience failed IVF, recurrent pregnancy loss, or both. If you’ve gone through various fertility treatments without success, you might start to feel like you’re running out of options, especially when doctors can’t seem to find the answers.

That’s why we developed the ReceptivaDx test. This first-of-its-kind test is designed to help you get to the root of unexplained infertility, restoring your hope in the chances of a successful pregnancy.

What is ReceptivaDx?

ReceptivaDx is the only test that can identify leading causes of unexplained infertility in a single sample including endometriosis, progesterone resistance, and endometritis. ReceptivaDx includes BCL6, a marker that identifies uterine lining inflammation most often associated with asymptomatic (silent) endometriosis. BCL6 is found in more than 50% of women with unexplained infertility and around 65% of women with two or more IVF failures.

Chart with data that shows the high IVF failures highly associated with BCL6 Presence with 5 or more IVF failures showing 71% positive for BCL6.

The ability to identify progesterone resistance via the BCL6 marker has been previously linked in published data to both implantation failure and recurrent pregnancy loss. Progesterone resistance is a condition that causes unfavorable changes on the uterine lining, blocking the important hormone progesterone from carrying out its vital role in embryo survival.

ReceptivaDx can also be used to identify endometritis, a chronic bacterial infection of the uterine lining, using a different marker called CD138. The good news for both providers and patients is that either a positive BCL6 or CD138 both have successful treatment options, significantly improving the chances for a successful pregnancy and live birth.

professional portrait of a new mom holding an infant while sitting in a chair.

“Our journey to our miracle baby has been one filled with heartache, frustration and many tears. However, through perseverance and a lot of hope, faith and the ReceptivaDx test, I am so happy to report that we finally had our beautiful blessing on 11-11-20. I consider the ReceptivaDX biopsy to be my miracle test, the test that allowed my baby girl to make it into my arms.”

– Melissa

Infant smiling at the camera wearing a "onesie" that says, "Worth Every Needle"

“We were losing all hope until we did the ReceptivaDx test. After we did it, we finally had an answer and a way forward. What I wouldn’t give to have been able to do it sooner.”

– Andrea

“We feel that the discovery from the ReceptivaDx test and the change in our protocol was what gave us the biggest gift in our lives, our sweet baby girl. We didn’t know what the future would hold for us for future children but to our surprise we got pregnant naturally with the first cycle after our first was born. These two baby girls are the absolute light of our lives and we hope that this test helps more families like ours.”

– Haley S.

Coulpe standing in front of palm trees outside holding a baby onsie announcing a pregnancy.

“After almost 3 years of unexplained infertility, 4 failed medicated IUI’s, and 3 failed embryo transfers, we felt completely defeated, hopeless, and unsure of our next steps. It’s an absolute miracle and I’m endlessly grateful for the ReceptivaDx test and the research that is currently being done to investigate the link between unexplained infertility and silent endometriosis.”

– Caroline C.

“After two egg retrievals and two failed transfers (with the loss of three embryos) my husband and I were in the depths of desperation and despair. It wasn’t until we switched clinics that we discovered Receptiva testing. The biopsy itself was quick and results were sent to my clinic in less than a week! We finally had an answer for our struggles and a clear path forward! I now have a sweet, silly, adorable ten-month-old thanks to the pioneering efforts of the team behind ReceptivaDx”

– Maggie B

close up picture of a new mom looking at her newborn.

“After my failed transfer with our first donated embryo I felt lost and broken. The PA at my office suggested that I research ReceptivaDx, she said it was new but could give me some answers, so I did. A few months later I had a 2nd transfer with our remaining donated embryo, and it worked! He is now a perfect, healthy 9 month old boy! Do yourself a favor, get this test! I had no symptoms, 1.5 years of infertility treatments and who knows if my journey would have been much shorter or a different outcome if I would have a had this test from the beginning!”

– Kerri Morgan

How do the test results help me?

Without treatment, women testing positive are 5 times less likely to succeed in IVF.

If positive for BCL6, current published data recommends two equally effective options:

Surgical laparoscopy to remove any endometriosis.
Hormone suppression therapy for 60 days which reduces the inflammation caused by endometriosis and provides a stable and viable surface for the embryo to grow.

If BCL6 is negative, provides assurance that uterine lining inflammation is not the primary cause of failed implantation and improves the probability of a successful transfer.

Useful Facts: Published studies show that women testing positive for BCL6 and left untreated have just an 11% chance of a successful live birth. Once treated, the probability goes up to over 60%. If negative, the probability is also above 60%.

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