In vitro fertilization (IVF) offers an alternative option to help women become pregnant, but when cycles fail, it may leave both patients and physicians needing answers. There are various reasons for unsuccessful IVF, such as an implantation that won’t take. ReceptiveDx offers a diagnostic test that gives insight into subtle uterine factors that can affect implantation. Here are a few explanations regarding IVF failure and what it could mean for your fertility journey:
Understanding Unexplained IVF Failure
IVF failure, even with quality embryos, can be a symptom of issues with the uterine lining. A ReceptivaDx test is an immunohistochemistry (IHC) assessment that analyzes a biopsy of the endometrium for markers of inflammation and dysfunction. The test searches for protein markers, such as BCL6, which may be associated with endometrial conditions and silent endometriosis.
Elevated BCL6 levels suggest that the uterine lining is not receptive due to immune dysfunction or progesterone resistance. The hormone progesterone, which is key for preparing the lining to accept the embryo, cannot function properly. Using the ReceptivaDx test helps detect chronic endometriosis, a condition characterized by low-grade inflammation of the uterine lining. The test also measures a second marker, CD138, which identifies chronic endometritis, another inflammatory condition of the uterine lining that can affect implantation.
Identifying Undiagnosed Endometriosis
Endometriosis, including mild or asymptomatic forms, is often underdiagnosed in women experiencing IVF failure. This is due to the fact that many cases show few or no symptoms. ReceptivaDx is a minimally invasive test that evaluates the endometrium for protein markers: BCL6, associated with endometriosis-related inflammation and potential progesterone resistance, and CD138, which identifies chronic endometritis. Elevated BCL6 suggests that inflammation may be affecting the lining’s ability to support embryo implantation. By detecting these underlying issues, ReceptivaDx can help guide targeted interventions to reduce inflammation and improve endometrial receptivity. This will potentially increase the chances of successful implantation.
Interpreting Potential ReceptivaDx Results
Once a positive result is identified, a physician may offer two treatment options: medical suppression and surgical intervention. Medical suppression involves a course of hormone therapy to address inflammation, and surgical intervention includes laparoscopy to locate and remove endometriotic lesions. If the test returns a negative result, it helps rule out a subset of uterine issues. Other causes, such as embryo quality, timing of transfer, or immunologic issues, might then become the focus of further evaluation. The ReceptivaDx test helps identify conditions in the uterine lining that may affect fertility and implantation success.
Developing a Fertility Strategy
Using ReceptivaDx in your diagnostic work-up provides actionable insights. The test involves an endometrial biopsy performed during the implantation window, seven to 10 days after ovulation or progesterone administration, and analyzes the sample for BCL6 and CD138. Based on the results, a fertility specialist can create a personalized treatment plan, which may include medical therapy or surgical removal of lesions.
By targeting the underlying factors affecting the uterine lining, these treatments can potentially improve implantation success in future cycles. If the test is negative and inflammation is ruled out, further IVF planning can proceed without unnecessary interventions. The ReceptivaDx test will help guide the fertility journey with better knowledge, supporting more informed decision-making.
Explore Alternative Fertility Options Today
IVF failure may result from multiple factors, so these issues should be evaluated and addressed before attempting future cycles. A ReceptivaDx test offers an option to reveal hidden, inflammation-related causes of implantation failure, such as silent endometriosis or chronic endometritis. With a precise diagnosis, patients can move forward with targeted treatment, addressing the root causes rather than just the symptoms. Whether your result is positive or negative, this test provides a medical team with key information that helps form a strategic approach to your fertility journey. Contact our team today to learn more about the ReceptivaDx test.