When IVF fails, or pregnancy loss recurs without a clear diagnosis, it’s key to identify the cause. Standard fertility workups evaluate embryo quality and transfer timing; some tests do not assess the uterine lining for inflammatory conditions that directly block implantation. A ReceptivaDx test helps women struggling with IVF fails. Here are some testing options for those experiencing unexplained infertility:
What Is Silent Endometriosis?
Endometriosis occurs when tissue that resembles the uterine lining grows outside the uterus. It may grow on:
- Ovaries
- Fallopian tubes
- Intestines
- Other pelvic structures
During each menstrual cycle, this tissue outside the uterus thickens and breaks down like the endometrium. The tissue doesn’t have a way to exit the body, so it becomes trapped. This causes inflammation, cysts, and adhesions that can interfere with implantation over time.
The reason silent endometriosis often goes undiagnosed is that it does not always produce symptoms. Some women have no pelvic pain, abnormal periods, or external signs of issues. The condition actively affects the uterine environment. Traditional diagnostic tools, including imaging, may struggle to detect this asymptomatic form of the disease. Because it goes undetected, it also goes untreated, and the underlying inflammation persists through fertility treatment. A ReceptivaDx test helps women with unexplained infertility by identifying the underlying cause and detecting specific protein markers.
What Does the Test Identify?
ReceptivaDx tests identify endometriosis, progesterone resistance, and endometritis from a single sample. It uses two markers: BCL6, which detects uterine lining inflammation associated with silent endometriosis, and CD138. This identifies endometritis, a chronic bacterial infection of the uterine lining. The BCL6 marker also identifies progesterone resistance; this condition causes changes to the uterine lining and prevents progesterone from functioning properly. Because progesterone directly prepares the lining for embryo survival, resistance to it creates conditions that work against implantation.
How Is the Test Administered?
The test is performed through an endometrial biopsy; this can be done during a standard office visit. Patients access testing through a reproductive specialist or their own OB-GYN. A locator tool on the ReceptivaDx website allows patients to search for testing providers by city, state, or zip code.
Some offices offer a free 20-minute phone consultation for those who need more information before scheduling an appointment. Patient advocates use this call to explain the test, walk through how results are interpreted, and clarify how ReceptivaDx fits into a broader fertility workup. This consultation does not replace a physician visit, but it can help patients come prepared with the right questions.
What Do the Results Mean?
A positive BCL6 result indicates two possible treatments: surgical laparoscopy to remove endometriosis tissue and a 60-day course of hormone suppression therapy. One confirms the condition, while the other helps reduce inflammation and stabilizes the uterine lining. Both options for treating endometriosis have been shown to improve conception rates even without IVF. A positive CD138 result indicates endometritis. Like a positive BCL6, this result has effective treatment options and, once addressed, may improve the likelihood of a successful pregnancy.
Learn More About Unexplained Infertility
Uterine lining inflammation, progesterone resistance, and chronic bacterial infection can all prevent implantation without producing symptoms that would otherwise prompt investigation. ReceptivaDx addresses this diagnostic gap directly, and it uses validated markers to detect these conditions in a single biopsy sample. For women who have experienced IVF failure or recurrent pregnancy loss without explanation, this test provides data that affects the treatment plan and outcome. Explore our website today to learn more about the test and its benefits.
