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Can I Get Treatment for Unexplained Infertility?

Getting diagnosed with unexplained infertility is frustrating, but it doesn’t mean one should lose hope.. Depending on age and the underlying cause, different types of treatment can be used for unexplained fertility. ReceptivaDx specializes in assessing the liklihood of uterine inflammation, most often associated with endometriois, one of the most common cause of unexplained infertility. Once diagnosed, treatment options such as surgical laparoscopy or hormon suppression are available.

General Treatment Options for Unexplained Infertility

Fertility doctors typically recommend first trying to conceive naturally for six months to one year, depending on age. If a patient is above 35 years, the fertility doctor may consider other treatment options after six months of unprotected sex. Some of the treatment plans include changing your lifestyle, medicines, and assisted reproductive technology. ReceptivaDx is a test specifically designed for woman with unexplained infertiltiy, who have failed IVF at least once, or have recurrent miscarraiges.  

Natural Conception

Natural conception as a form of treatment is suitable only when tests have established that one’s infertility is unexplained. Fertility doctors do not advise continuing with natural conception before getting tested since certain infertility conditions worsen over time. Our fertility specialists at ReceptivaDX can perform comprehensive fertility tests and observe the patient’s response before suggesting any treatment plan.

Lifestyle Changes

Positive lifestyle changes are linked to improved fertility. Some of the lifestyle changes one can practice to increase their chances of getting pregnant include:

  • Limit alcohol consumption
  • Reduce caffeine intake
  • Keeping a healthy weight and exercising frequently
  • Reduce stress
  • Avoid using tobacco and other substance abuse
  • Maintain a balanced diet

Timed Sexual Intercourse

Conception occurs within a short fertility period of a woman’s menstrual cycle. It’s possible to determine this period by monitoring the woman’s temperature, keeping track of their cycle, or using ovulation prediction kits.

At ReceptivaDX, we can make it easier for one to identify this window to increase their chances of becoming pregnant. Our experts offer advice on how to determine ovulation and plan for sex appropriately.

Intrauterine Insemination (IUI)

IUI works by inserting clean sperm into the wall of the uterus during the ovulation period. It can either be done using ovulation-inducing medications or through natural ovulation with the assistance of an LH kit.

Clomid and gonadotropins are the most used ovulation induction drugs. Gonadotropins are costly and have a higher risk of multiple pregnancies than Clomid. For this reason, Clomid is mostly preferred by specialists.

The number of IUI treatments varies according to age and willingness to undergo IVF. Three rounds of IUI with Clomid may be enough if one would be willing to proceed to IVF. If not, the patient may have to take up to six cycles of IUI with fertility medications.

In Vitro Fertilization (IVF)

IVF is a series of operations that entails fertilizing an egg outside a woman’s uterus in a specialist facility. It has a higher chance of success than other methods when treating unexplained infertility. IVF makes it easy to monitor egg quality, fertilization, and embryo growth. Going directly for IVF instead of IUI may be the best option if one is over 35 years.

It’s usually carried out after other fertility treatment procedures have failed. IVF can be performed using the patient’s eggs or from a donor. Specialists extract mature eggs from the ovaries, fertilize them in a laboratory using sperm, and then transfer them to the uterus. It takes time to complete one IVF cycle since the steps are divided into separate phases.

IVF failures are the most common reason doctors order ReceptivaDx, Almost 50% of women will fail at least once. If the underlying cause is endometriosis, studies show success on the next transfer will only be 12% without specific treatment such as laparoscopy which surgically removes endometriosis or hormone suppression which quiets the inflamation,

Talk to a Fertility Specialist

Unexplained infertility is frustrating to everyone and makes fertility doctors  consider many options to determine the underlying condition.  A patient should find a qualified specialist to help them explore many different fertility options. Visit us at ReceptivaDx for more information.

Bruce Lessey, M.D., Ph.D. – Scientific Advisor
Lessey’s Corner

The ReceptivaDxTM Test was developed by Cicero Diagnostics in conjunction with Pathology Consultants, Inc. of Greenville, SC. Pathology Consultants, Inc. is a laboratory certified under the Clinical Laboratory Improvement Amendments (CLIA). As with other laboratory-developed tests, this testing service has not been cleared or approved by the US FDA or any other federal regulatory agencies. Data have not been submitted to or evaluated by Federal regulatory agencies and the test is not for sale as an In Vitro Diagnostic (IVD) in the US or the EU.


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