Preexisting health conditions in a woman’s body can affect the chances for successful in vitro fertilization. Progesterone resistance is a possible cause of IVF failure. Here is more information about how progesterone resistance impacts IVF success:
Progesterone
Progesterone is a hormone that helps regulate the menstrual cycle and maintain pregnancy. It assists the body with preparing for fertilized egg implementation after ovulation by thickening the uterine lining. Without fertilization, the hormone levels drop, and the menstruation cycle occurs, shedding the uterine lining. When fertilization happens, progesterone continues to be produced, maintaining the lining during pregnancy. It also helps stop contractions that have the possibility of resulting in miscarriage.
Infertility and IVF Failure
Progesterone resistance is a condition where a woman’s body tissues are less responsive to this hormone. The lining does not react correctly, which can result in irregular periods or ovulation. These factors can impact one’s fertility.
Resistance to this hormone can be a possible cause of infertility and can cause IVF failure. For some patients, progesterone resistance causes the uterine lining to be overly thick or thin when the body is preparing for embryo implementation. During IVF treatment, a woman’s eggs are fertilized with sperm outside of the womb, and then the embryo is placed back into the uterus. Progesterone resistance causes abnormalities in the uterine lining, lowering the chances of successful implementation and resulting in a lack of IVF success.
Miscarriage is another possible result of progesterone resistance. If one successfully becomes pregnant, the resistance of progesterone during early pregnancy means a lack of support for the uterine environment. This can mean pregnancy loss. Progesterone resistance can also cause recurring miscarriages.
BCL6 Testing
BCL6 testing allows individuals to check if progesterone resistance is a factor in their infertility or unsuccessful IVF implementations. Women who are experiencing unexplained infertility issues and who have experienced unsuccessful IVF cycles are candidates for BCL6 testing. BCL6 is a protein that is associated with uterine lining and tissue conditions, including endometriosis and progesterone resistance. Endometriosis refers to tissue growth outside of the uterus. This condition can interfere with hormone signaling, causing progesterone resistance. ReceptivaDx tests for endometriosis and progesterone resistance using a single sample from the uterine lining to check for BCL6.
If the test returns with high levels of BCL6, this may show the presence of progesterone resistance. Knowing the cause of infertility and unsuccessful IVF treatment allows fertility doctors to adjust treatment plans for their patients, specifically targeting the condition. One treatment method is increasing progesterone sensitivity. This can help improve the chances of IVF treatment success.
Learn More About ReceptivaDx
A doctor is able to perform ReceptivaDx during a typical visit. Interested patients should discuss ReceptivaDx with their doctor before the visit. After the sample is taken, the physician ships the sample and receives results about five to six days after the sample has been delivered. CiceroDx provides fertility patients who would like to learn more about ReceptivaDx with a free 20-minute phone consultation. Call today to find out more about the ReceptivaDx testing process and results.