Unexplained infertility may involve various factors, such as hormonal imbalances or affected reproductive organs. If patients have undergone several fertility treatments with no success, a ReceptivaDx test may help. This test helps find the root cause of infertility to treat endometriosis. Here’s how hormones affect fertility and how a test will help identify the cause:

Hormone Imbalances

If a patient struggles to get pregnant, one cause may be a hormone imbalance. When the menstrual cycle is irregular, it can affect the regularity of ovulation and fertility. Some hormones affect conception by causing ovulatory dysfunction. If patients ovulate very early or late, or not at all, it may be a struggle to get pregnant. A short cycle can also release hormones too early, not allowing time for the egg to implant in the womb. 

With the help of a physician and test, it will help narrow down the root cause. The test may detect any hormone imbalances. Some treatment options include a biopsy procedure or providing a sample to determine the condition of unexplained infertility

Conditions Caused by Imbalances

Hormone imbalances, irregular ovulation cycles, or issues may cause various medical conditions. Some cases revolve around having too many or too few hormones, which causes several symptoms, such as polycystic ovary syndrome (PCOS). Other conditions or issues related to a patient’s health can include anovulation.

Patients may struggle with endometriosis, which is a common fertility issue. Endometriosis involves clumps of tissue that grow outside the uterus, usually around the ovaries or fallopian tubes. The growth usually develops into endometrial cysts, causing scar tissue and interfering with the menstrual cycle.

ReceptivaDx Test

A ReceptivaDx test provides an immunohistochemistry option that helps identify conditions associated with endometriosis including silent endometriosis, where no symptoms are occurring. The test screens all stages of the condition and helps patients who struggle with infertility, IVF failure, or limited embryo reserves.

An endometriosis test is done through a biopsy procedure and sample submission. The biopsy procedure uses a standard pipelle, which is then shipped for testing. A biopsy is done to see how hormones affect fertility through a BCL6 analysis. If the BCL6 protein marker is detected, it is associated with endometriosis. A positive result is associated with inflammation of the uterine lining caused by the body’s response to the condition. 

Treatments for Unexplained Infertility

Some options available may determine the patient’s specific condition, medical history, and more. The outcome of the test is also a factor in the type of treatment. Some treatment plans available for a positive test include letrozole, gonadotropin-releasing hormone (GnRH) agonists, or laparoscopic surgery. Depending on other results, a combination of ampicillin, gentamicin, and metronidazole provides protection from chronic endometritis. 

Review ReceptivaDx Tests For Hormone Imbalances

Unexplained infertility may be caused by multiple factors, including endometriosis. A ReceptivaDx test helps provide answers using a biopsy procedure and detecting BCL6 protein markers. If the results are positive, treatment options are available to increase the success rates on the next transfer almost five-fold. Patients struggling with hormone imbalances, infertility, or recurrent pregnancy loss are qualified candidates for the test. Treatment options, including laparoscopy, are available depending on the test results. Reach out to our team today for more information about the testing, treatments, and more.

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