Women undergoing IVF may be faced with unexplained infertility. This means that standard testing has not identified the cause. Hormonal imbalances and hidden conditions in the uterine lining can be the reason, and identifying these factors provides patients with answers. ReceptivaDx offers insights into what is affecting IVF success, which helps doctors create a more effective treatment plan. Here is the role of hormonal imbalances in unexplained fertility:
Identifying Hormonal Imbalances
Hormones help regulate ovulation, and they prepare the uterine lining for implantation. They also support the early stages of pregnancy. When communication between hormones is disrupted, it can cause unexplained infertility.
Progesterone plays a key role in this process. It prepares the uterus to receive an embryo by thickening the uterine lining. Progesterone resistance occurs when the uterine lining does not respond effectively, which means implantation cannot take place. It is also possible for this resistance to cause irregular ovulation or menstrual cycles. Estrogen, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) influence ovulation. They are also responsible for endometrial development, and imbalances interfere with the timing that is necessary for pregnancy.
Hormonal disruptions can be difficult to detect. This is because routine fertility testing measures hormone levels at specific points in time. It may not evaluate how tissues respond to them. This causes underlying conditions to remain hidden, and some patients face repeated failed cycles without clear explanations. A thorough evaluation of hormonal health can offer women an improved chance of pregnancy success. Additional hormonal challenges that affect fertility include:
- Hormonal changes may affect egg quality. They influence how well embryos develop in early stages.
- Shifts in thyroid hormone levels may alter reproductive function; they are sometimes overlooked in standard evaluations.
- Insulin resistance disturbs ovarian activity, which contributes to irregular cycles that complicate fertility treatment.
Exploring Endometriosis and Inflammation
Endometriosis can contribute to infertility. This condition occurs when tissue grows outside the uterus; this triggers chronic inflammation. Misplaced tissue may form lesions that lead to scarring, which causes few or no symptoms. This sometimes causes the condition to remain undetected. Silent endometriosis may alter the environment of the uterus. It releases inflammatory molecules that interfere with hormone signaling, which makes the uterine lining less receptive to an embryo. This can increase the possibility of implantation failure even when an embryo is healthy.
Conventional imaging techniques, such as ultrasounds, may not detect lesions. Routine fertility testing does not usually evaluate for silent endometriosis, which means it goes unrecognized. This causes the underlying issue to remain hidden. ReceptivaDx is an advanced diagnostic test that identifies hidden inflammation and silent endometriosis markers, which gives patients clearer insight into whether this condition is affecting their fertility. Additional factors of silent endometriosis include:
- Silent endometriosis can affect egg quality, and it also impacts the developing embryo’s ability to thrive.
- The presence of this inflammation disrupts the healthy communication between the uterine lining and embryo.
- Endometriosis can affect a woman’s reproductive organs and cause damage to the fallopian tubes or ovaries.
Address Unexplained Infertility Today
Infertility can be due to hormone imbalances, and this may not appear in routine tests. Understanding these factors helps patients address the underlying causes. ReceptivaDx looks for specific markers such as BCL6, which indicates inflammation associated with endometriosis. It also looks for CD138, which helps to identify chronic uterine infection. Women who test positive for these markers and go untreated may face lower chances of IVF success. With ReceptivaDx, we help patients identify these issues early, allowing doctors to create a treatment plan to help improve the likelihood of a successful pregnancy. Contact ReceptivaDx today to schedule consultations and address unexplained infertility.